en فارماکولوژی Pharmacology پژوهشي Original Research <strong>Background</strong>: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions.<br> <strong>Objectives</strong>: This study aims to evaluate the A. sinkatana plant&rsquo;s anti-psoriatic properties.<br> <strong>Methods</strong>: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean&plusmn;SD was used.&nbsp;<br> <strong>Results</strong>: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups&rsquo; psoriasis area and severity index (PASI) scale.<br> <strong>Conclusion</strong>: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.&nbsp; Aloe sinkatana, Dermatitis, Extracts, Imiquimod (IMQ), Psoriasis area and severity index (PASI), Mice 41 48 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1362-2&slc_lang=en&sid=1 Azza Dawoud Hussien Dawoud azzadawoudhussien@gmail.com 100319475328460010962 0009-0004-9847-8148 Yes Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan. Mohammed Abdalbagi Mohammed.abdalbagi@gmail.com 100319475328460010963 100319475328460010963 No Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan.