en فارماکولوژی Pharmacology پژوهشي Original Research <div style="text-align: justify;"><strong>Background</strong>: Psoriasis is a chronic, untreatable and disabling disease.&nbsp;<br> <strong>Objectives</strong>: In this research, we investigated the pharmacological properties of Euphorbia milii petroleum ether and ethyl acetate in a psoriasis mouse model.&nbsp;<br> <strong>Methods</strong>: Thirty-one albino mice were used in this study. They were divided into five groups: group I, healthy animals; group II, inducer group with imiquimod 12.5 mg (5% cream); and groups III, IV and V were imiquimod-induced and then treated with clobetasol 0.05% in group III, E. milii petroleum ether fraction in group IV and E. milii ethyl acetate fraction in group V. Immunohistochemistry for interleukin-17 (IL-17), vascular endothelial growth factor and transforming growth factor-beta, as well as histopathology were done on the mice skin.<br> <strong>Results</strong>: E. milii petroleum ether group showed a significant decrease in skin immunohistochemistry of IL-17, transforming growth factor-beta, and other histopathology parameters, while ethyl acetate fraction showed a significant reduction in vascular endothelial growth factor and other histopathology parameters<br> <strong>Conclusion</strong>: E. milii petroleum ether and ethyl acetate fractions may have a role in psoriasis treatment in a mice model.</div> Euphorbia milii, Interleukin-17 (IL-17), Imiquimod, Psoriasis, Vascular endothelial growth factor (VEGF) 157 166 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1295-1&slc_lang=en&sid=1 Mohammed Fareed Hameed dr.mohammed.fared@nahrainuniv.edu.iq 100319475328460010423 100319475328460010423 Yes Department of Pharmacology and Toxicology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq. Ayah F. Al-Qrimli ayah.hrhr@yahoo.com 100319475328460010424 0009-0000-2631-2318 No Department of Pharmacognosy, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.