en فارماسیوتیکس Pharmaceutics پژوهشي Original Research <div style="text-align: justify;"><strong>Background</strong>: Limited diabetes drug availability and frequent adverse reactions to oral medications highlight the need for improved drug delivery.<br> <strong>Objectives</strong>: This study suggests optimizing drug efficiency through process modifications, focusing on anti-diabetic medications like metformin hydrochloride. Matrix-type formulations are utilized to overcome current drug targeting and dosage management limitations.<br> <strong>Methods</strong>: This study aims to improve anti-diabetic drugs, focusing on metformin hydrochloride, via process modifications in drug delivery. We developed a sustainable drug release process with matrix-type formulations, comparing hydroxyl propyl methylcellulose (HPMC) and guar gum as rate-controlling polymers. The optimized formulation was then compared with Glyciphage SR 500 to identify similarities and differences in drug release profiles.<br> <strong>Results</strong>: We utilized matrix-type formulations to administer metformin hydrochloride. It develops a sustainable drug release process with HPMC and guar gum as rate-controlling polymers. Next, we conducted comparative drug release studies, systematically optimized the formulation, and compared it to Glyciphage SR 500 using appropriate analytical methods. &nbsp;Comparative dissolution data, including a high similarity factor (f2) of 75.33 with Glyciphage SR 500, emphasizes the promising resemblance between metformin hydrochloride tablet (MT5) and the market sample, warranting further stability studies for potential upscaling.<br> <strong>Conclusion</strong>: The study&#39;s novelty lies in successfully formulating sustained-release MT5 using HPMC K100M and guar gum via wet granulation, demonstrating a potential reduction in dosing frequency and adverse effects. MT5&#39;s optimal physical and chemical parameters and sustained drug release exceeded 99% at 12 hours.</div> In vitro techniques, Metformin, Polymers, Sustained release formulation, Tablets 121 134 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1247-1&slc_lang=en&sid=1 Amlan Bishal bishalamlan31@gmail.com 100319475328460010405 100319475328460010405 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Biplab DEbnath biplab.d86@gmail.com 100319475328460010406 100319475328460010406 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Bikash Gayen bikashgayen3@gmail.com 100319475328460010407 0009-0006-6980-4455 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Bratati Bandyopadhyay bratatibanerjee92@gmail.com 100319475328460010408 0009-0001-4592-8625 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Surjendu Payra surjendupayra453@gmail.com 100319475328460010409 0009-0003-4629-0306 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Rishav Maji majirishav2001@gmail.com 100319475328460010410 0009-0007-2391-9975 No Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. Kazi Asraf Ali asraf03@gmail.com 100319475328460010411 100319475328460010411 Yes Division of Pharmaceutics, Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Kolkata, India.