Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1399
3
1
gregorian
2020
6
1
6
2
online
1
fulltext
en
The Effect of Hydroalcoholic Rosmarinus Officinalis (Rosemary) on Memory Retention Deficit in Young Offspring Rat Induced by Maternal Sleep Deprivation
بیولوژی سلولی- مولکولی
Cellular and Molecular Biology
پژوهشي
Original Research
<p style="text-align: justify;"><strong>Background</strong>: Maternal sleep deprivation is known to reduce neurogenesis in the hippocampus during pregnancy. Also, it damages and impairs cognitive functions such as learning and memory in the neonates. <br>
<strong>Objectives</strong>: Rosmarinus officinalis (rosemary) extract can play an important role in the treatment of cognitive impairments by inhibiting oxidative stress. This study aimed to investigate the role of hydroalcoholic extract of rosemary in the treatment of cognitive impairment caused by decreased hippocampal neurogenesis in neonates, which was attributed to maternal sleep deprivation during pregnancy.<br>
<strong>Methods</strong>: For this purpose, pregnant rats in the control group underwent sleep deprivation for 72 hours inside a total sleep deprivation machine. The treatment groups comprised pregnant rats, receiving 50, 100, and 200 mg/kg of rosemary extracts per day during pregnancy and underwent sleep deprivation for 72 hours. Next, the avoidance memory of 21-day-old neonatal rats was examined using a shuttle box. These 21-day-old rats were then subjected to evaluate the structure of the hippocampus. Neurogenesis in the neonatal hippocampus was examined under light microscopy by staining of brain slices and counting of neurons and cells shape study.<br>
<strong>Results</strong>: Compared with the control group, the neurogenesis and avoidance memory decreased in neonates affected by maternal sleep deprivation.<br>
<strong>Conclusion</strong>: The results of this study showed that rosemary extract at a dose of 100 mg/kg was able to improve disorders in the infants affected by maternal sleep deprivation.</p>
Maternal sleep deprivation, Cognitive impairment, Memory deficit, Hippocampus, Neurogenesis, Oxidative stress, Rosemary
157
168
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-792-1&slc_lang=en&sid=1
Fatemeh
Khodabandeh Shahraki
fatemeh.khodabandeh@gmail.com
10031947532846005411
10031947532846005411
No
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Mohammad
Nabiuni
devbiokharazmi@gmail.com
10031947532846005412
10031947532846005412
Yes
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Mona
Farhadi
farhadi@kiau.ac.ir
10031947532846005413
10031947532846005413
No
Department of Microbiology, Karaj branch, Islamic Azad University, Karaj, Iran
Elaheh
Amini
elah.amini73@gmail.com
10031947532846005414
10031947532846005414
No
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran