Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1399
9
1
gregorian
2020
12
1
6
1
online
1
fulltext
en
Malathion-increased Hepatotoxicity in Diabetic Rats
سم شناسی
Toxicology
پژوهشي
Original Research
<div style="text-align: justify;"><strong>Background</strong>: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. <br>
<strong>Objectives</strong>: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. <br>
<strong>Methods</strong>: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined. <br>
<strong>Results</strong>: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe.<br>
<strong>Conclusion</strong>: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system. </div>
Organophosphorus, Diabetes, Liver, Oxidative stress
53
60
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-775-1&slc_lang=en&sid=1
Seyedeh Azam
Hosseini
azam32259@yahoo.com
10031947532846005127
10031947532846005127
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ahmad
Ahmadipour
ahmadipourahmad@yahoo.com
10031947532846005128
10031947532846005128
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Motahareh
Soltani
motahareh.soltani@gmail.com
10031947532846005129
10031947532846005129
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad
Mehdipour
eankpen2008@yahoo.com
10031947532846005130
10031947532846005130
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ali
Mandegary
alimandegary@yahoo.com
10031947532846005131
10031947532846005131
No
Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Somayyeh
Karami-Mohajeri
somayyehkarami@gmail.com
10031947532846005132
10031947532846005132
Yes
Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.