Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1398
6
1
gregorian
2019
9
1
5
3
online
1
fulltext
en
Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice
سم شناسی
Toxicology
پژوهشي
Original Research
Capparis<em> spinosa L. </em>(caper) is an aromatic plant, commonly used in the Mediterranean diet, possessing numerous antioxidant compounds, such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the present study investigated the effects of Iranian caper leaves extract on oxidative stress caused by CCl<sub>4</sub> in the mice’s liver.This study was conducted on 42 male mice in seven groups. The control group, the sham group, the CCl<sub>4</sub> group, the Iranian caper leaves extract 100, 200, and 400 mg/kg + CCl<sub>4 </sub>groups. Then, Biochemicals, oxidative stress, and hepatic histopathology parameters were evaluated. The co-administration of Iranian caper leaves extract, and CCl<sub>4</sub> significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species, malondialdehyde (<em>P</em><0.001) and significantly increased the levels of glutathione and catalase in comparison with the group treated with CCl<sub>4</sub> alone (<em>P</em><0.01). Furthermore, Iranian caper leaves extract improved histopathological changes such as the the inflammation and necrosis of hepatocytes. Iranian caper leaves extract has protective effects on hepatotoxicity induced by CCl<sub>4,</sub> mainly through suppressing oxidative stress.
Iranian caper, Carbon tetrachloride, Oxidative stress, Liver, Mice
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http://pbr.mazums.ac.ir/browse.php?a_code=A-10-709-1&slc_lang=en&sid=1
Heibatullah
Kalantari
kalantarih@yahoo.com
10031947532846003998
10031947532846003998
No
Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Anis
Alijani
Aalijanianis@yahoo.com
10031947532846003999
10031947532846003999
No
Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Parvin
Kheradmand
Dr.kheradmandpar64@yahoo.com
10031947532846004000
10031947532846004000
No
Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Maedeh
Goodarzian
dr_maedehg@yahoo.com
10031947532846004001
10031947532846004001
No
Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Leila
Zeidooni
leilazeidooni@gmail.com
10031947532846004002
10031947532846004002
Yes
Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran