Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1393
10
1
gregorian
2015
1
1
1
1
online
1
fulltext
en
Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity
شیمی دارویی
Medical Chemistry
مروری
Review article
<p>Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables. Kojic acid is a naturally-occurring tyrosinase inhibitor which has been clinically used to treat the hyperpigmentation of skin. However, kojic acid as a hydrophilic small-molecule has insufficient inhibitory activity and stability, with considerable toxicity. To overcome these drawbacks, synthetic derivatives of kojic acid were developed, which exhibited enhanced tyrosinase inhibitory activity and more favorable stability relative to kojic acid. In this context, the synthesis and biological activity of kojic acid derivatives as tyrosinase inhibitors have been highlighted.</p>
Kojic acid, 4H-pyran-4-one derivatives, enzyme inhibitors, structural modifications
1
17
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-1&slc_lang=en&sid=1
Seyedeh Mahdieh
Hashemi
10031947532846001286
10031947532846001286
No
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Saeed
Emami
10031947532846001287
10031947532846001287
Yes
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran