en فارماسیوتیکس Pharmaceutics پژوهشي Original Research The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The <em>in vitro</em> dissolution parameters (%DE_10min, %DE_30min, %DE_60min, T_50% and DP₃₀) were used to select the optimized solid dispersion that was characterized by IR, PXRD, DSC and SEM. The optimized solid dispersion of GLIM (GSDSM3) was used as drug component for immediate release (IR) tablets that were evaluated for physical and pharmacopoeial parameters. The <em>in vitro</em> drug release studies identified G4 as the optimized tablet with a cumulative drug release (CDR) of 99.34% in 30 min in phosphate buffer, pH 7.4. The CDR was higher than the marketed tablet (91.15%, Amaryl&reg;, Sanofiaventis), However, the <em>f1</em> and <em>f2</em> were 10.6 and 52 respectively, which confirmed similarity of the dissolution profile(s). Accelerated stability studies confirmed stability up to 6 months at 40&deg;C/75% condition in the HDPE bottle pack. Glimperide, solid dispersion, solvent wetting method, solvent melt method, immediate release tablet 1 13 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-6&slc_lang=en&sid=1 Suchitra Kaushik suchitra.kaushik@gmail.com 10031947532846003832 10031947532846003832 No Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Etawah, 206130, INDIA Kamla Pathak kamlapathak5@gmail.com 10031947532846003831 10031947532846003831 Yes Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Etawah, 206130, INDIA