Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1396
6
1
gregorian
2017
9
1
3
3
online
1
fulltext
en
Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells
بیولوژی سلولی- مولکولی
Cellular and Molecular Biology
پژوهشي
Original Research
Cold atmospheric plasma (CAP) has received great attention due to its noteworthy ability, and has also been widely studied over few decades in physics, biology and medicine. The purpose of this study is to evaluate the cold atmospheric pressure plasma effects on the proliferation of breast cancer cells. MDA-MB-231 was used for this experiment. MDA-MB-231 cells were cultured in 24-well plate and treated with non-thermal plasma. The viability of the cancer cells was determined by MTT assay. Different input power was applied in this experience (20-35W), and treatment time was between 5s and 25s. For reducing thermal damage, gas temperature was less than 37 ˚C. The Viability of breast cancer cells was significantly decreased after plasma treatment. The results showed that viability was decreased with an increment of plasma power and plasma exposure time. These results suggest that non-thermal atmospheric pressure plasma could strongly have cytotoxicity effect on cancerous breast cell.
non-thermal plasma, cancer cells, cell viability, MTT assay, MDA-MB-231
12
16
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-311-1&slc_lang=en&sid=1
Ramin
Mehrabifard
std_r.mehrabifard@khu.ac.ir
10031947532846003811
10031947532846003811
Yes
Department of physics and institute for plasma research, kharazmi University, Mofatteh avenue Tehran, Iran
Hassan
Mehdian
mehdian@khu.ac.ir
10031947532846003812
10031947532846003812
No
Department of physics and institute for plasma research, kharazmi University, Mofatteh avenue Tehran, Iran
mahdi
bakhshzadmahmodi
Mdmahmoudi@aeoi.org.ir
10031947532846003813
10031947532846003813
No
Nuclear Science and Technology Research Institute (NSTR), Plasma and Nuclear Fusion school, A,E,O, I, Tehran Iran