en فارماسیوتیکس Pharmaceutics پژوهشي Original Research Uremic pruritus is a common and distressing symptom that affects more than 40% of patients undergoing hemodialysis. Several medications as well as topical preparation have been used for relief this condition. <em>Sambucus ebulus</em> has been shown anti-inflammatory and wound healing effects. In this research, the antipruritic effect of <em>S. ebulus</em> fruit extract was evaluated on patients with uremic pruritus.<em> S. ebulus</em> fruits were collected from Sari suburb, Iran. Fruits were dried at room temperature and several fractions of extract were prepared. After formulating suitable gel (2%) a randomized, single blind, placebo-controlled clinical trial was performed in 78 patients (40 patients received <em>S. ebulus</em> topical gel 2% and 38 patients received placebo gel) for 8 weeks and the changes in hyperuremic induced pruritus severity were evaluated. Sixty one patients completed the study. The Pruritus severity index was reduced in both groups after 8 weeks&rsquo; treatment. <em>S. ebulus</em> topical gel showed more effect than placebo, but this difference was not statistically significant. The results showed that <em>S. ebulus</em> topical gel can reduce uremic pruritus severity, and more study with higher extract concentration or more cases is proposed. Uremic pruritus, sambucus ebulus, topical preparation, clinical trial 26 32 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-32-7&slc_lang=en&sid=1 Naghme Jabbar Imani 10031947532846003774 10031947532846003774 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Majid Saeedi majsaeedi@gmail.com 10031947532846003775 10031947532846003775 Yes Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Zohreh Hajheydari 10031947532846003776 10031947532846003776 No Department of Dermatology, Boo Ali Sina (Avicenna) Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Ali Ebrahimzadeh 10031947532846003777 10031947532846003777 No Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Katayoun Morteza-Semnani 10031947532846003778 10031947532846003778 No Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran