Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1394
10
1
gregorian
2016
1
1
2
4
online
1
fulltext
fa
In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp.
داروسازی و طب سنتی
Medicine and traditional medicine
پژوهشي
Original Research
<p style="text-align: justify;">Candida species are the most common cause of opportunistic fungal infection worldwide. Due to increasing resistance of fungi against conventional drugs, as well as their side effects, alternative natural products have become a renewed interest. In the current study, the anti-Candida activities of <em>Scrophularia striata</em> extract were examined. In this experimental study, microdilution assay and well diffusion test were used to determine <em>invitro</em> anti-fungal effects of ethanolic and methanolic extract of <em>Scrophulari astriata</em> on four species of Candida including <em>Candida albicans ATCC 1167</em>, <em>ATCC 1677</em>, <em>tropicalis</em>, and <em>glabrata</em>. The results showed that 100 mg/ml methanolic extract has more anticandida activity than ethanolic extract. Diameter of inhibiting growth environment for ethanol extract was 37 mm, and MIC and MFC were 2.1 and 41.5 mm/ml. Results show that ethanolic and methanolic extract of <em>Scrophularia striata</em> have anti-fungal activities. Therefore results of this study suggest this extract is a promising anti-fungal agent, and future experiments will interest for performing <em>in vivo</em> study.</p>
Scrophulariastriata, Candida, ehanolic extract, methanolic extract
38
43
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-77-2&slc_lang=fa&sid=1
Mandana
Ahmadi
10031947532846001249
10031947532846001249
Yes
Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran
Hossein
Mahdavi
10031947532846001250
10031947532846001250
No
Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran
Mahboobeh
Madani
10031947532846001251
10031947532846001251
No
Department of Microbiology, Falavarjan Branch,Islamic Azad University, Isfahan, Iran
Zohreh
Hadadi
10031947532846001252
10031947532846001252
No
Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran