%0 Journal Article %A Yousef, Bashir A. %A Awad, Zeinab %A Adam, Somaya %A Abdelgadir, Setalbanat %A Mergani, Ansam %T Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats %J Pharmaceutical and Biomedical Research %V 7 %N 1 %U http://pbr.mazums.ac.ir/article-1-345-en.html %R 10.18502/pbr.v7i1.7356 %D 2021 %K Anacyclus pyrethrum, Gas chromatography-mass spectrometry (GC/MS), Pentylenetetrazole, Anticonvulsant activity, %X Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of Anacyclus pyrethrum on pentylenetetrazole (PTZ)-induced seizure model in Wistar rats. Methods: The composition of the petroleum ether extract of A. pyrethrum was first analyzed using gas chromatography-mass spectrometry (GC-MS). Subsequently, the anticonvulsant activities of these extracts (70 and 140 mg/kg, intraperitoneal injection) were evaluated on PTZ-induced seizures in rats. The protection rate against induced seizures, latency, and duration of seizures, as well as neurological symptoms, were assessed and compared to those protected by phenobarbital. Results: GC/MS analysis of the petroleum ether extract showed that the main components were octadecadienoic acid, hexadecanoic acid, diheptylcyclopropene, naphthalene, and methyl stearate. The extract (70 and 140 mg/kg) was found to provide significant protection against PTZ-induced seizures. Moreover, compared to the negative control, the extracts increased the latency of induced-convulsion and reduced the duration of epilepsy. Interestingly, the extracts showed a reduction in neurological symptoms and the severity of seizures compared to the negative control. All of these outcomes manifested in a dose-dependent manner. Conclusion: The petroleum ether extract of A. pyrethrum may produce anticonvulsant effects by reducing the duration of seizures and delaying the latency of seizures induced by PTZ. %> http://pbr.mazums.ac.ir/article-1-345-en.pdf %P 47-54 %& 47 %! %9 Original Research %L A-10-863-1 %+ Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan. %G eng %@ 2423-4486 %[ 2021