TY - JOUR T1 - Malathion-increased Hepatotoxicity in Diabetic Rats TT - JF - mazums-pbr JO - mazums-pbr VL - 6 IS - 1 UR - http://pbr.mazums.ac.ir/article-1-280-en.html Y1 - 2020 SP - 53 EP - 60 KW - Organophosphorus KW - Diabetes KW - Liver KW - Oxidative stress N2 - Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined. Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe. Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system. M3 10.18502/pbr.v6i1.3428 ER -