AU - Ghandadi, Morteza TI - Inhibitory Effects of Salinispora-derived Metabolites Against Multidrug Resistance: An In-silico Study PT - JOURNAL ARTICLE TA - mazums-pbr JN - mazums-pbr VO - 7 VI - 1 IP - 1 4099 - http://pbr.mazums.ac.ir/article-1-364-en.html 4100 - http://pbr.mazums.ac.ir/article-1-364-en.pdf SO - mazums-pbr 1 ABĀ  - Background: Multi drug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites. Objectives: In this study, the potential of Salinispora derived metabolites as inhibitor of ATP-binding cassette (ABC) transports have been investigated using in-silico approaches. Methods: Physicochemical, pharmacokinetic and drug likeness of the Salinispora derived metabolites have been analyzed using SwissADME server. This was accompanied by the employment of docking strategy to evaluate anti-MDR potential of the metabolites using P-gp, Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP-1) as target proteins. Results: Nineteen metabolites were found to have demonstrated appropriate physicochemical, pharmacokinetic, and drug-likeness properties and were involved in the docking studies. Based on docking studies, saliniquinones, cyclomarazine, and cyanosporoside A demonstrated ABC transporters inhibitory potential. Conclusion: Our results suggest that further in vivo and in vitro studies on anti-MDR effects of Salinispora-derived metabolites are warranted. CP - IRAN IN - Department of Pharmacognosy And Pharmaceutical Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Email: Ghandadi@yahoo.com LG - eng PB - mazums-pbr PG - 25 PT - Original Research YR - 2021