RT - Journal Article T1 - Proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy JF - mazums-pbr YR - 2015 JO - mazums-pbr VO - 1 IS - 4 UR - http://pbr.mazums.ac.ir/article-1-73-en.html SP - 1 EP - 11 K1 - Peraxisome prolifrator-activated receptors (PPARs) K1 - metabolic processes K1 - Fatty acid (FA) K1 - diabetic cardiomyopathy (DCM) K1 - PPARĪ± K1 - PPARĪ“ AB - Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. As development of diabetes leads to functional and structural alterations at the myocardium termed diabetic cardiomyopathy (DCM), metabolic controller seems to be able to affect on cardiomyocytes. Herein, the role of PPARα, and PPARδ, is emerged and compared. This minireview discusses about these receptors in diabetes. LA eng UL http://pbr.mazums.ac.ir/article-1-73-en.html M3 10.18869/acadpub.pbr.1.4.1 ER -