Volume 1, Issue 4 (December 2015)                   mazums-pbr 2015, 1(4): 29-39 | Back to browse issues page


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Danafar H. A quick and easy high performance liquid chromatography method for evaluation of cefixime in human plasma . mazums-pbr. 2015; 1 (4) :29-39
URL: http://pbr.mazums.ac.ir/article-1-77-en.html
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:   (1967 Views)

Cefixime is essential member of orally energetic third generation cephalosporin and has tremendous activity aligned with many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation.  A simple and available reversed-phase HPLC method with UV detection has been urbanized and validate for cefixime evaluate in human plasma using a C18 analytical column and a mobile phase of tetrabutylammonium hydroxide (pH 6.5)-acetonitrile (3:1 v/v). The detection wavelength was 280 nm. To method observed major linear response-concentration association all through the cefixime concentration range of 15-100 ng/ml, with the average accuracy within-run and between-run values of 97.29% and 99.27%. The average drug recovery from plasma was 98.2% throughout the linear concentration range. The limits of detection (LOD) and quantitation (LOQ) of the method were 5 and 15 ng/ml, respectively. The method is quick, easy, very steady and precise for the partition, assignment, evaluation of cefixime in human plasma.

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Type of Study: Research | Subject: Drug Analysis

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