Volume 7, Issue 1 (2021)                   Pharm Biomed Res 2021, 7(1): 63-66 | Back to browse issues page

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Ghanbarzamani A H, Salehifar E, Kazemian K. A Case of Erythema Multiforme Caused by Sildenafil Plus Tramadol. Pharm Biomed Res 2021; 7 (1) :63-66
URL: http://pbr.mazums.ac.ir/article-1-361-en.html
A Case of Erythema Multiforme Caused by Sildenafil Plus Tramadol
Amir Hossein Ghanbarzamani * 1, Ebrahim Salehifar1 , Kaveh Kazemian2
1- Pharmaceutical Research Center, Department of Clinical pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Clinical Pharmacy, Sina Hospital, Tehran University of Medicine, Tehran, Iran.
Abstract:   (1718 Views)
In this report, we present a 29-year-old man who experienced EM five days after using sildenafil and tramadol. Based on clinical examination and history, the diagnosis of EM was made confirmed via skin biopsy, which found intra-epidermal bulla filled by fibrinous exudate, some mononuclear cells, and a few eosinophils. The spongiotic epidermis showed lichenoid interface dermatitis, eosinophilic spongiosis, and necrolysis, consistent with EM diagnosis. Fluocinolone, 0.025% ointment, was prescribed for the patient, and the lesions healed after two weeks of treatment.
Keywords: Erythema multiforme, Sildenafil, Tramadol
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Type of Study: case report | Subject: Drug Clinical Investigation
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