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The world is grappling for US FDA-approved therapies for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). It is the virus that has caused Coronavirus Disease 2019 (COVID-19). Several pharmacological drugs are under various phases of clinical trials, and their current clinical use is primarily based on the in vitro activity against SARS-CoV-2 or related coronaviruses.  While the efficacy of drug therapies is yet to be established, and the efficacy of the vaccine for COVID-19 is to be accomplished, we need to focus on prophylactic measures. The current article describes the chemoprophylactic, Ayurvedic, homeopathic, and Unani prophylactic approaches for combating COVID-19 based on the guidelines issued by the Ministry of AYUSH, India. The article is based on the guidelines issued by the Ministry of AYUSH, India. The proposed approaches have been supported by scientific evidence. The article also provides an outlook on the global scenario of herbal practices. In the absence of effective treatment, efforts to control the COVID-19 pandemic heavily rely on non-pharmaceutical interventions such as personal preventive measures. The alternative system of medicine offers prophylactic solutions that are simple and inexpensive. These simple measures will go a long way in tackling the pandemic.

Keywords: Coronavirus, COVID-19, Prophylaxis, Chemoprophylaxis, Ayurvedic, Homeopathic, Unani

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