Volume 3, Issue 2 (2017)                   Pharm Biomed Res 2017, 3(2): 1-7 | Back to browse issues page

‎ 10.29252/pbr.3.2.1

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Development and characterization of rozuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia
Ankit Jain1 , Naina Dubey1 , Asmita Gajbehiye2 , Sheilendra Patil * 3
1- Sagar Institute of Pharmaceutical Sciences, Sagar (M.P), India
2- Department of Pharmaceutical Sciences, Dr H. S. Gour University, Sagar (M.P), India
3- SVNInstitute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar (M.P), India
Abstract:   (4959 Views)

The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple emulsification technique, six batches i.e. f1 to f6 were prepared by varying the concentration of oils, surfactant, co-surfactant and co-solvent and evaluated for the various parameters, e.g. optical microscopy, assessment of self emulsification, emulsification time, droplet size analysis, zeta potential measurement, transmission electron microscopy, viscosity determination, drug content, percentage transmittance, in vitro dissolution study and stability studies. The RSEDDS was optimized and batch F5 was opted for further studies. The drug content of selected batch F5 was found to be 97.65 ± 1.37%, which suggests that method for encapsulation was effective. The results of in vitro drug release studies showed about 83% of the drug release within 180 minutes, which exhibit sustained release of drug. There were no significant changes observed in the physical appearance, drug content and in vitro release during stability studies. The studies reveal that the RSEDDS is a potential candidate for sustained release drug delivery which can successfully increase bioavailability.

Keywords: Self-emulsifying drug delivery system, rosuvastatin, sustained release, tem, in vitro release
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Type of Study: Original Research | Subject: Pharmaceutics
References
1. 1. Jain NK, Sharma SN. A text book of professional pharmacy. 5th edition published by N. K. Jain for VallabhPrakashan New Delhi 2008;1-11.
2. 2. Sharma S, Sharma AD, Chauhan B, Sanwal R. Self Emulsifying Drug Delivery Systems: A Modern Approach for Delivery of Lipophilic Drug. Ordonear Research Library 2011; 1:121-2.
3. 3. Jing LT, Jin S, Zhong GH. Self-Emulsifying Drug Delivery Systems: Strategy for Improving Oral Delivery of Poorly Soluble Drugs. Curr Drug ther 2007; 2:85-93. [DOI:10.2174/157488507779422400]
4. 4. Ngiik T, Amal AE. Effects of liquid solid formulations on dissolution of naproxen. ‎Eur J PharmBiopha 2009;73:373-84. [DOI:10.1016/j.ejpb.2009.08.002]
5. 5. Hentzschel CM, Alnaief M, Smirnova I, Sakmann A, Leopold CS. Enhancement of griseofulvin release from liquid solid compacts. Eur J PharmBiopha 2011;73:1-6.
6. 6. Vijay KN, Ramarao T, Jayaveera KN. Liquisolid compacts: A novel approach to enhance bioavailability of poorly soluble drugs. Int JPharm BioSci 2011;1:89-102.
7. 7. Sachan R, Khatri K, Kasture SB. Self-Eumlsifying Drug Delivery System: A Novel Approach for enhancement of bioavailability. IntJ Pharm Tech Res 2010;2:1738-45.
8. 8. Patel NN, Rathva SR, Shah VH, Upadhyay UM. Review on self emulsifying drug delivery system: Novel approach for solubility enhancement. IntJPharm Resallied sci2012;1:1-12.
9. 9. Patel PA, Chaulang GM, Akolkotkar A, Mutha SS, Hardikar SR,Bhosale AV. Self emulsifying drug delivery system: A Review. Research J.Pharm. and Tech. 2008;1:313-23.
10. 10. Jingling T, Jin S, Fude C, Zhonggui H. Preparation of Self-emulsifying Drug Delivery Systems of Ginkgo biloba Extracts and In vitro Dissolution Studies. AsianJ Traditional Medicines 2006;1: 1-4.
11. 11. Khoo SM, Humberstone AJ, Porter CJ, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self- emulsifying formulations of halofantrine. Int J Pharm 1998;167:155-64 [DOI:10.1016/S0378-5173(98)00054-4]
12. 12. Naisarg DP. Self-emulsifying drug delivery system: A novel approach. Int J CurPharmRes 2012;4:18-23.
13. 13. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Hong MJ, Jee JP. Enhanced oral bioavailability of coenzyme Q10 by a novel solid self-emulsifying drug delivery system. Int J Pharm2009; 74:66-72. [DOI:10.1016/j.ijpharm.2009.03.008]
14. 14. Bhatt PP. Osmotic Drug Delivery Systems for Poorly Soluble Drugs, The Drug Delivery Companies Report Autumn/Winter 2004, 26-29.
15. 15. Kavita S, Ashu S, Singh SK, Saloni K. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs. Indo Global J Pharm Sci 2012;2:313-32.
16. 16. Dhomne, Formulation and evaluation of solid self emulsifying drug delivery system for lipophyllic drugs, International Journal of Pharmaceutical Sciences Review and Research. 2012; 3:32-36.
17. 17. Himani B, Seema B, Mayank Y, Vinod S, Mamta S. Self emulsifying drug delivery system: An approach to enhance bioavailability. International Journal of Pharma. Research and Development 2008;3:59-75.
18. 18. Pathak CV, Gujarathi NA, Rane BR, Pawar SP.A review on self micro emulsifying drug delivery system. IntJ Pharm Sci 2013; 4:3628-48.
19. 19. Liang M, Davies NM, Toth I. Increasing entrapment of peptides from water in oil Microemulsions by copolymerization. Int J Pharm 2008; 362:141-6. [DOI:10.1016/j.ijpharm.2008.06.005]
20. 20. Yogeshwar G, Vandana B. SMEDDS of Glyburide: Formulation, in vitro evaluation, and stability studies. AAPS Pharm Sci Tech 2009;10:482-7. [DOI:10.1208/s12249-009-9234-1]
21. 21. Tayal A, Jamil F, Sharma R, Sharma S. Self emulsifying drug delivery system: A review. International Research Journal of Pharm 2012;3:32-6.
22. 22. Sharma S, Bajaj H, Bhardwaj P, Sharma AD, Singh R.Development and Characterization of self emulsifying drug delivery system of poorly water soluble drug using natural oil. Acta Pol Pharm 2012;69:713-7.
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