Pharmaceutical and Biomedical Research

en A notable side effect of gabapentin in a patient with low back pain: A Case Report کارآزمایی بالینی دارو Drug Clinical Investigation گزارش مورد case report Introduction: Gabapentin was originally designed to treat epilepsy, but it was soon discovered to have significant effects in reducing pain caused by nerve damage. The exact mechanism of action of this drug is still not completely clear, but studies have shown that gabapentin binds to the α2δ subunit of voltage-gated calcium channels in neurons. Here I will introduce a patient that is one of the rare cases of urinary problems following the use of gabapentin. Case Presentation: A 52-year-old man presented with lower back pain that prescribed Gabapentin 100 mg capsules for nighttime use to reduce pain and improve sleep. Following the medication, the patient experienced urinary frequency, waking up 4 to 5 times during the night, and bifurcate urination. Laboratory tests and urinalysis were normal. The patient had not had these symptoms before the medication. After 3 days of stopping the medication, the symptoms resolved without any further intervention, and the patient returned to normal. After 9 months of follow-up, the patient had no problems urinating. MRI, laboratory tests, and urine tests have been used for diagnosis. Written informed consent was obtained from the patient and is included in the Supplementary Information section. An ethical approval code number IR.BUMS.REC 1404.353 was obtained from the Research Ethics Committees of Birjand University of Medical Sciences. Discussion: It is recommended that neurologists pay attention to urinary side effects when prescribing this drug, especially in older people.   Gabapentin, Urinary Frequency, low back pain 0 0 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1515-1&slc_lang=en&sid=1 mahdi eslami eslami.m@bums.ac.ir Yes